ACCOMPLISH

Cardiovascular clinical trial, phase III. ACCOMPLISH was stopped for benefit. A+ Science was responsible for Scandinavia and contributed to study design.

ACCOMPLISH compared the effects of two forms of antihypertensive combination therapies on major fatal and nonfatal cardiovascular events. In total, 11 400 men and women aged 55 years or older who had systolic blood pressure >160 mm Hg or were currently on antihypertensive therapy and who had evidence of cardiovascular or renal disease or target-organ damage were included in the trial. Patients enrolled in the trial were obese, with 60% having diabetes mellitus, and nearly all had been treated previously for hypertension.

A+ Science contribution:

  • Coordination in Scandinavia 
    • Center Selection (n=155)
    • Patient recruitment (n=3353)
    • Clinical Monitoring
  • ECG handling and central reading (> 30 000)

 


Return to case study list

Study details

  • Stopped early for benefit
  • Conducted in 5 countries
  • More than 11 000 patients enrolled at 550 sites

Read more

The New England Journal of Medicine 2008; 359:2417-2428

Blood Pressure 2008; 17: 7-17

Blood Pressure 2007; 16: 80-86

Blood Pressure 2007; 16: 13-19

American Journal of Hypertension 2004; 17:793-801